DD205-291

• Description:

  DD205-291 is an orally active PROTAC HPK1 degrader, with a DC50 value of 5.3 nM. DD205-291 inhibits SLP-76 phosphorylation and induces IL-2 and IFN-γ expression (Pink: HPK1 protein ligand HY-168283; E3+linker: HY-168284; Blue: E3: HY-W115490; Black: linker: HY-W210252) [1].

• UNSPSC:

  12352005

• Target:

  MAP4K; PROTACs

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway; PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dd205-291.html

• Smiles:

  O=C(N1)N(C2=C(C=CC(C(N3CCC(CC3)CC4CCN(CC4)C5=CC=C(C=N5)C6=NC7=C(NC=C7C8=CN(N=C8)CC(F)(F)F)N=C6)=O)=C2)Cl)CCC1=O

• Molecular Formula:

  C38H38ClF3N10O3

• Molecular Weight:

  775.22

• References & Citations:

  [1]Zhang Z, et al. Discovery of Novel PROTAC-Based HPK1 Degraders with High Potency and Selectivity for Cancer Immunotherapy. J Med Chem. 2024 Nov 14;67 (21) :18682-18698.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3047066-15-6]