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LP-6

CAT: 0804-HY-157079Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-157079Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LP-6 is a Drug-Linker Conjugate for ADC, and can be used for synthesis of ADCs. LP-6 consists of an Eg5 inhibitor and a linker[1].
CAS Number
[1629736-79-3]
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC; Kinesin
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lp-6.html
Solubility
10 mM in DMSO
Smiles
CC([C@H](C1=NC(C2=CC(F)=CC=C2F)=CN1CC3=CC=CC=C3)N(C[C@H]4[C@H](CNC4)F)C([C@@H](O)C)=O)(CC(NCCN5C(C=CC5=O)=O)=O)C
Molecular Formula
C36H41F3N6O5
Molecular Weight
694.74
References & Citations
[1]Karpov AS, et al. Discovery of Potent and Selective Antibody-Drug Conjugates with Eg5 Inhibitors through Linker and Payload Optimization. ACS Med Chem Lett. 2019 Dec 3;10 (12) :1674-1679.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Kinesin-5/Eg5/KSP

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