LP-65

• Description :

  LP-65 is a dual inhibitor of MEK (IC50=83.2 nM) and mTOR (IC50=40.5 nM) . LP-65 blocks MEK and mTOR signaling pathways and inhibits tumor cell proliferation and migration. LP-65 is promising for research of cancers[1].

• UNSPSC :

  12352005

• Target :

  MEK; mTOR

• Related Pathways :

  MAPK/ERK Pathway; PI3K/Akt/mTOR

• Field of Research :

  Cancer

• Smiles :

  FC1=C(F)C(NC2=C(F)C=C(I)C=C2)=C(C(NOCCOCCOCCOCCC(OCC3=CC(C4=CC=C(C(N5CCOC[C@@H]5C)=NC(N6CCOC[C@@H]6C)=N7)C7=N4)=CC=C3OC)=O)=O)C=C1

• Molecular Formula :

  C47H53F3IN7O10

• Molecular Weight :

  1059.86

• References & Citations :

  [1]Van Dort ME, et al. Synthesis and Biological Evaluation of MEK/mTOR Multifunctional Inhibitors as Novel Anticancer Agents. J Med Chem. 2025 Jun 12;68 (11) :11406-11418.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported