LP-403812

• Description:

  LP-403812 is a high affinity proline transporter (PROT) inhibitor that produces dose-dependent inhibition of hPROT (IC50=0.11 μM; Ki=0.12 μM) and also inhibits the activity of mouse brain synaptosomal mPROT with the same potency (IC50=0.23 μM) . LP-403812 can be used to study the function of PROT in the brain[1].

• UNSPSC:

  12352005

• Target:

  Amino acid Transporter

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/lp-403812.html

• Smiles:

  O=C (NC1=NC (N (C (C) (C) C) N=C2C (N3[C@H] (CN4CCCC4) CCC3) =O) =C2S1) C5=CC=C (C) C=C5

• Molecular Formula:

  C26H34N6O2S

• Molecular Weight:

  494.65

• References & Citations:

  [1]XuanChuan Yu, et al. "Discovery and characterization of potent small molecule inhibitors of the high affinity proline transporter." Neuroscience letters 451.3 (2009) : 212-216.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1142050-84-7