UCM-1336

• Description :

  UCM-1336 is a potent ICMT inhibitor, with an IC50 of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Autophagy

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ucm-1336.html

• Purity :

  99.48

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(CCN(CCCCCCCC)CCC(NC1=CC=CC=C1)=O)NC2=CC=CC=C2

• Molecular Formula :

  C26H37N3O2

• Molecular Weight :

  423.59

• References & Citations :

  [1]Nagore Marín-RamosA, Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia. J Med Chem. 2019 Jul 11;62 (13) :6035-6046.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1621535-90-7]