UCM-1336

• Description:

  UCM-1336 is a potent ICMT inhibitor, with an IC50 of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Autophagy

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ucm-1336.html

• Purity:

  99.48

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(CCN(CCCCCCCC)CCC(NC1=CC=CC=C1)=O)NC2=CC=CC=C2

• Molecular Formula:

  C26H37N3O2

• Molecular Weight:

  423.59

• References & Citations:

  [1]Nagore Marín-RamosA, Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia. J Med Chem. 2019 Jul 11;62 (13) :6035-6046.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1621535-90-7]