UCM-A86

• Description :

  UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors with EC50 values of 21 µM and 19 µM at GluN1/GluN3A and GluN1/GluN3B receptors, respectively. UCM-A86 selectively potentiates responses from GluN1/GluN3A/B over GluN1/GluN2A-D receptors. UCM-A86 can be used in the research of central nervous system diseases[1].

• UNSPSC :

  12352005

• Target :

  IGluR

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  FC(C1=NN=C2C=CC(SC3=CC=C(C(C)C)C=C3)=NN21)(F)F

• Molecular Formula :

  C15H13F3N4S

• Molecular Weight :

  338.35

• References & Citations :

  [1]Benton AJ, et al. UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors. bioRxiv [Preprint]. 2025 Nov 16:2025.11.14.688378.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NMDA Receptor

• CAS Number :

  [1210899-51-6]