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UCM-1306

CAT: 0804-HY-148867-01Size: 5 mgDry Ice: NoHazardous: No
CAT#: HY-148867-01Size: 5 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UCM-1306 is a potent and orally active human dopamine D1 receptor allosteric modulator (PAM) . UCM-1306 increases the endogenous dopamine (DA) maximal effect both in human and mouse D1 receptors. UCM-1306 is not only for improving motor symptoms but also for addressing the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD) [1].
CAS Number
[2258608-78-3]
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ucm-1306.html
Purity
99.61
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(C2=C(OCF)C=CC=C2)C=C1)(C)=N
Molecular Formula
C14H14FNO2S
Molecular Weight
279.33
References & Citations
[1]García-Cárceles J, et, al. 2- (Fluoromethoxy) -4'- (S-methanesulfonimidoyl) -1,1'-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson's Disease. J Med Chem. 2022 Sep 22;65 (18) :12256-12272.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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