UCM-1306

• Description:

  UCM-1306 is a potent and orally active human dopamine D1 receptor allosteric modulator (PAM) . UCM-1306 increases the endogenous dopamine (DA) maximal effect both in human and mouse D1 receptors. UCM-1306 is not only for improving motor symptoms but also for addressing the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD) [1].

• UNSPSC:

  12352005

• Target:

  Dopamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ucm-1306.html

• Purity:

  99.61

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=S(C1=CC=C(C2=C(OCF)C=CC=C2)C=C1)(C)=N

• Molecular Formula:

  C14H14FNO2S

• Molecular Weight:

  279.33

• References & Citations:

  [1]García-Cárceles J, et, al. 2- (Fluoromethoxy) -4'- (S-methanesulfonimidoyl) -1,1'-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson's Disease. J Med Chem. 2022 Sep 22;65 (18) :12256-12272.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2258608-78-3]