UCM-13369 (dihydrochloride)

• UNSPSC Description:

  UCM-13369 (Compound 4b) is a NPM1 inhibitor. UCM-13369 downregulates the pathway associated with mutant NPM1 C+, and specifically recognizes the C-end DNA-binding domain of NPM1 C+. UCM-13369 induces apoptosis in AML cell lines and primary cells. UCM-13369 can be used for leukemia research[1].

• Target Antigen:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ucm-13369-dihydrochloride.html

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  N[C@@H]([C@@H]1CCNCC2CC2)[C@@H](C3=CC=C(OC)C=C3)CC4=C1C5=C(N4)C=CC=C5.Cl.Cl

• Molecular Weight:

  462.46

• References & Citations:

  [1]Algar S, et al. Cancer-Stem-Cell Phenotype-Guided Discovery of a Microbiota-Inspired Synthetic Compound Targeting NPM1 for Leukemia. JACS Au. 2024.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported