UCM 608

• Description:

  UCM 608 is a high affinity melatonin (MT) membrane receptor agonist. The pKi values for MT1 and MT2 are 10.7 and 10.4[1][2].

• Product Name Alternative:

  2-Phenylmelatonin

• UNSPSC:

  12352005

• Target:

  Melatonin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ucm-608.html

• Concentration:

  10mM

• Purity:

  99.18

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CC (NCCC1=C (C2=CC=CC=C2) NC3=C1C=C (OC) C=C3) =O

• Molecular Formula:

  C19H20N2O2

• Molecular Weight:

  308.37

• References & Citations:

  [1] Radogna F, et al. Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes. Toxicol Appl Pharmacol. 2009;239 (1) :37-45.|[2]Mor, M., et al. Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands. Bioorganic & Medicinal Chemistry, 9 (4), 1045–1057.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MT1; MT2

• CAS Number:

  151889-03-1