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UCM 793

CAT: 0804-HY-115304Size: 1 EachDry Ice: NoHazardous: No
HY-1153041 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UCM 793 is a non-selective MT1/MT2 receptor agonist (pKis: 9.09 (MT1 receptor) ; 9.19 (MT2 receptor) ) . UCM793 increases the number of episodes and decreases the length of the episodes of wakefulness. UCM 793 influences quality of the vigilance states. UCM 793 decreases sleep onset without having an effect on NREM sleep maintenance[1][2].
CAS Number
[101374-18-9]
UNSPSC
12352005
Target
Melatonin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(NCCN(C=1C=CC=C(OC)C1)C)C
Molecular Formula
C12H18N2O2
Molecular Weight
222.29
References & Citations
[1]Ochoa-Sanchez R, et al. Melatonin, selective and non-selective MT1/MT2 receptors agonists: differential effects on the 24-h vigilance states. Neurosci Lett. 2014 Feb 21;561:156-61.|[2]Jockers R, et al. Update on melatonin receptors: IUPHAR Review 20[J]. British journal of pharmacology, 2016, 173 (18) : 2702-2725.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MT1; MT2

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