UCM 793

• Description :

  UCM 793 is a non-selective MT1/MT2 receptor agonist (pKis: 9.09 (MT1 receptor) ; 9.19 (MT2 receptor) ) . UCM793 increases the number of episodes and decreases the length of the episodes of wakefulness. UCM 793 influences quality of the vigilance states. UCM 793 decreases sleep onset without having an effect on NREM sleep maintenance[1][2].

• UNSPSC :

  12352005

• Target :

  Melatonin Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(NCCN(C=1C=CC=C(OC)C1)C)C

• Molecular Formula :

  C12H18N2O2

• Molecular Weight :

  222.29

• References & Citations :

  [1]Ochoa-Sanchez R, et al. Melatonin, selective and non-selective MT1/MT2 receptors agonists: differential effects on the 24-h vigilance states. Neurosci Lett. 2014 Feb 21;561:156-61.|[2]Jockers R, et al. Update on melatonin receptors: IUPHAR Review 20[J]. British journal of pharmacology, 2016, 173 (18) : 2702-2725.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MT1; MT2

• CAS Number :

  [101374-18-9]