NPD-2975

CAT: 0804-HY-155732-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-155732-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT) . NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC500 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC50 values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19, respectively[1].
CAS Number
[3032452-65-3]
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/npd-2975.html
Solubility
10 mM in DMSO
Smiles
O=C1C(NN=C2C(C)C)=C2N=C(C3=CC=C(F)C=C3)N1
Molecular Formula
C14H13FN4O
Molecular Weight
272.28
References & Citations
[1]Zheng Y, et al. Discovery of 5-Phenylpyrazolopyrimidinone Analogs as Potent Antitrypanosomal Agents with In Vivo Efficacy. J Med Chem. 2023 Aug 10;66 (15) :10252-10264.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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