NPD-1335

• Target:

  Parasite|||Others|||PDE

• Related Pathways:

  Others|||Metabolism|||Microbiology/Virology

• Bioactivity:

  NPD1335, a potent inhibitor of Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1), exhibits submicromolar activity against T. brucei parasites and an improved cytotoxicity profile. By elevating intracellular cAMP levels, NPD1335 disrupts the cell cycle, leading to cell death [1].

• Smiles:

  [H][C@]12CC=CC[C@@]1([H])C(=NN(C(C)C)C2=O)c1ccc(OC)c(c1)C#CC(=O)NCc1ccccc1

• Molecular Formula:

  C28H29N3O3

• Molecular Weight:

  455.55

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2376326-31-5