GGTI-297

GGTI-297

• CAS Number: 181045-83-0
• UNSPSC Description: GGTI-297 is a geranylgeranyl transferase I (GGTase-1) inhibitor with IC50 values of 56 nM and 203 nM for GGTase-1 and fanesyl transferase (FTase), respectively. GGTI-297 inhibits the processing of the geranylgeranylated protein Rap1A without affecting the farnesylated protein H-Ras[1][2].
• Target Antigen: Ras
• Type: Reference compound
• Related Pathways: GPCR/G Protein;MAPK/ERK Pathway
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ggti-297.html
• Smiles: CC(C)C[C@@H](C(O)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=C3C=CC=CC3=CC=C2)=O
• Molecular Weight: 465.61
• References & Citations: [1]J Sun, et al. Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts. Oncogene. 1998 Mar;16(11):1467-73. |[2]Y Qian, et al. Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics. Bioorg Med Chem. 1998 Mar;6(3):293-9.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported