NPD-1335

• Description :

  NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. brucei parasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAMP levels and results in the distortion of the cell cycle and cell death[1]. NPD-1335 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• CAS Number :

  [2376326-31-5]

• UNSPSC :

  12352005

• Target :

  Parasite; Phosphodiesterase (PDE)

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/npd1335.html

• Purity :

  98.10

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(NCC1=CC=CC=C1)C#CC2=CC(C3=NN(C(C)C)C([C@@]4([H])CC=CC[C@@]34[H])=O)=CC=C2OC

• Molecular Formula :

  C28H29N3O3

• Molecular Weight :

  455.55

• References & Citations :

  [1]de Heuvel E, et al. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2) . Bioorg Med Chem. 2019 Jul 5. pii: S0968-0896 (19) 30790-4.|[2]Erik de Heuvel, et al. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2) . Bioorg Med Chem. 2019 Jul 5. pii: S0968-0896 (19) 30790-4.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Trypanosoma