PI3K-IN-41

• UNSPSC Description:

  PI3K-IN-41 (compound 2) is a photocaged compound, as well as a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties. PI3K-IN-41 has potential to be used in precisely controlled cancer therapeutics. PI3K-IN-41 exhibits potent PI3K ihibition upon UV light irradiation, and enhances antitumor effect[1].

• Target Antigen:

  PI3K

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/pi3k-in-41.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC(COC2=CC3=C(C=C(C(O3)=O)CN(S(C4=C(C=C(C=C4)F)F)(=O)=O)C5=C(N=CC(C6=CC7=C(N=CN=C7C(OC8CCOCC8)=C6)C)=C5)OC)C=C2)=C(C=C1OC)[N+]([O-])=O

• Molecular Weight:

  911.88

• References & Citations:

  [1]Tian H, et al. Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release. ACS Med Chem Lett. 2023 Jul 24;14(8):1100-1107.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported