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PI3Kα-IN-14

CAT: 0804-HY-157125Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157125Size:1 Each
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Description
PI3Kα-IN-14 (compound F8) is a selective PI3Kα inhibitor with an IC50 of 0.14 nM. PI3Kα-IN-14 induces a great decrease in mitochondrial membrane which caused cell cycle arrest at G1 phase and apoptosis in U87-MG cells. PI3Kα-IN-14 shows significant anti-proliferative activities against three tumor-derived cell lines (PC-3: IC50 of 0.28 μM; HCT-116: IC50 of 0.57 μM; and U87-MG: IC50 of 1.37 μM) [1].
CAS Number
3026856-46-9
UNSPSC
12352005
Target
Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3kα-in-14.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCN(C2=NC(N3C(C(F)F)=NC4=C(OC)C=CC=C34)=NC(N5CCOCC5)=N2)CC1)NNC(C6=CC=C(Cl)C=C6)=O
Molecular Formula
C28H29ClF2N10O4
Molecular Weight
643.04
References & Citations
[1]Siyu Fu, et al. Structure-based drug design, synthesis, and biological evaluation of novel 1,3,5-triazine or pyrimidine derivatives containing benzoyl hydrazine moiety as PI3Kα selective inhibitors. Bioorg Chem. 2023 Nov:140:106738.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

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