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AChE-IN-34

CAT: 0804-HY-155713Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155713Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE-IN-34 (compound 5l) is a potent and selective AChE inhibitor with an IC50 value of 3.98 µM with no significant inhibition against BChE. AChE-IN-34 inhibits AChE with a Ki of 0.044 μM in a mixed mode (Acetylthiocholine substrate; 0.1-1 mM) [1].
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-34.html
Solubility
10 mM in DMSO
Smiles
NC1=C(C#N)C2(C3=C(NC2=O)C=CC([N+]([O-])=O)=C3)C([N+]([O-])=O)=C(NC4=CC=C(O)C=C4)NN1
Molecular Formula
C19H14N8O6
Molecular Weight
450.36
References & Citations
[1]Hormoz Pourtaher, et al. The anti-Alzheimer potential of novel spiroindolin-1,2-diazepine derivatives as targeted cholinesterase inhibitors with modified substituents. Sci Rep. 2023 Jul 24;13 (1) :11952.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE

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GTR19230456-01AChE-IN-34
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