MOR agonist-3

• Description:

  MOR agonist-3 (Compound 84) is a D3R/MOR antagonist/partial agonist a (Ki 382 nM and 55.2 nM respectively) . MOR agonist-3 has the potential to produce analgesic effects through MOR (μ-opioid receptor) (HY-149337) partial agonists and to reduce opioid abuse through D3R antagonists. MOR agonist-3 can be used in the treatment of inflammation and neuropathic pain research[1].

• UNSPSC:

  12352005

• Target:

  Dopamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/mor-agonist-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (N (C) C) C (C1=CC=CC=C1) (C2=CC=CC=C2) CCN[C@H]3[C@H] (C4=CC=CC=C4OC) C3

• Molecular Formula:

  C28H32N2O2

• Molecular Weight:

  428.57

• References & Citations:

  [1]Bonifazi A, et al. Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics. J Med Chem. 2023 Aug 10;66 (15) :10304-10341.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported