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OX2R agonist 3

CAT: 0804-HY-163276Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163276Size:1 Each
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Description
OX2R agonist 3 (compound 63c) is an agonist for orexin receptor type 2 (OX2R) with EC50 of 339 nM. OX2R agonist 3 is able to cross the blood-brain barrier and exhibits no cytotoxicity in cells[1]
UNSPSC
12352005
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ox2r-in-2.html
Solubility
10 mM in DMSO
Smiles
CC(C=C1)=CC=C1C[C@@H](COCCOC)N2C3=NC=CC=C3N(C(C)C4=CC=C(C)C=C4)C2=N
Molecular Formula
C28H34N4O2
Molecular Weight
458.60
References & Citations
[1]Wang W, et al., Novel orexin receptor agonists based on arene- or pyridine-fused 1,3-dihydro-2H-imidazole-2-imines. Bioorg Med Chem Lett. 2024 Feb 1;99:129624.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
OX2 Receptor

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