TREM2 agonist-3

• Description:

  TREM2 agonist-3 (Compound 4i) is a TREM2 agonist, with a KD value of 19.0 µM. TREM2 agonist-3 shows a KD value of 39.8 µM for TREM1. TREM2 agonist-3 induces an increase in phospho-SYK levels. TREM2 agonist-3 can be used in the research of neurodegenerative diseases and other diseases involving TREM2 dysfunction[1].

• UNSPSC:

  12352100

• Target:

  Syk; TREM receptor

• Related Pathways:

  Immunology/Inflammation; Protein Tyrosine Kinase/RTK

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Purity:

  99.39

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC (C1=CC=C (S1) C2=CC (C (NC) =O) =CC (NC (C3CC (C3) =C) =O) =C2OC) =O

• Molecular Formula:

  C21H22N2O4S

• Molecular Weight:

  398.48

• References & Citations:

  [1]Nada H, et al. TREM2 Activation by First-in-Class Direct Small Molecule Agonists: DEL Screening, Optimization, Biophysical Validation, and Functional Characterization. bioRxiv [Preprint]. 2025 May 27:2025.05.22.655617.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TREM-1; TREM-2