MOR agonist-2

• UNSPSC Description:

  MOR agonist-2 (compound 46) is a antagonist of D3R and agonist of MOR (Ki: 7.26 nM and 564 nM, respectively). MOR agonist-2 has the potential to produce analgesic effects through MOR partial agonism. MOR agonist-2 reduces opioid-misuse liability via D3R antagonism[1].

• Target Antigen:

  Dopamine Receptor; Opioid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/mor-agonist-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@H]1N(CCC(C2=CC=CC=C2)(C3=CC=CC=C3)C(N(C)C)=O)C[C@H](O)C1)NCCCCN4CCN(C5=CC=CC(Cl)=C5Cl)CC4

• Molecular Weight:

  680.71

• References & Citations:

  [1] Bonifazi A, et al. Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics. J Med Chem. 2023 Aug 10;66(15):10304-10341.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2833692-02-5