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D3R/MOR antagonist 2

CAT: 0804-HY-149387Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149387Size:1 Each
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Description
D3R/MOR antagonist 2 (Compound 121) is a D3R/MOR antagonist (Ki: 361 nM and 85.2 nM respectively) . D3R/MOR antagonist 2 has the potential to produce analgesic effects through MOR partial agonism, reduce opioid-misuse liability via D3R antagonism[1].
CAS Number
3033883-17-6
UNSPSC
12352005
Target
Dopamine Receptor; Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/d3r-mor-antagonist-2.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(C=C1)[C@H]2[C@@H](C2)NCCC3(C4=NC=CC=C4)CC5(CCCC5)OCC3
Molecular Formula
C25H31ClN2O
Molecular Weight
410.98
References & Citations
[1]Bonifazi A, et al. Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics. J Med Chem. 2023 Aug 10;66 (15) :10304-10341.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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