DprE1-IN-6

DprE1-IN-6

• UNSPSC Description: DprE1-IN-6 (Compound 56) is a DprE1 inhibitor. DprE1-IN-6 has anti-TB activity against Mtb H37Rv strain (MIC: 1 μM). DprE1-IN-6 also has antimycobacterial activity against drug-resistant strains. DprE1-IN-6 has high microsomal stability and medium clearance[1].
• Target Antigen: Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/dpre1-in-6.html
• Solubility: 10 mM in DMSO
• Smiles: CCNC1=C2N(CC3=CC=C4C=CC=CC4=C3)C=NC2=NC(N5CCOCC5)=N1
• Molecular Weight: 388.47
• References & Citations: [1]Finger V, et al. 2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1. Eur J Med Chem. 2023 Oct 5;258:115611.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported