DprE1-IN-13

• Description:

  DprE1-IN-13 (Compound 42) is the inhibitor for decaprenyl-phosphoryl-β-d-ribose oxidase (DprE1) with IC50 of 12.72 μM. DprE1-IN-13 inhibits Mycobacterium tuberculosis H37Ra with MIC50 of 1.071 μM[1].

• UNSPSC:

  12352005

• Target:

  Bacterial

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Smiles:

  O=C(NN/C=C1C(N(CC#C)C(NC/1=O)=O)=O)C2=CC=NC=C2

• Molecular Formula:

  C14H11N5O4

• Molecular Weight:

  313.27

• References & Citations:

  [1]Liang J, et al., Discovery of novel pyrimidinetrione derivatives as DprE1 inhibitors with potent antimycobacterial activities. Eur J Med Chem. 2025 Feb 18;289:117416.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported