DprE1-IN-1

DprE1-IN-1

• CAS Number: 920459-41-2
• UNSPSC Description: DprE1-IN-1 is a potent, orally active DprE1 inhibitor with favorable hepatocyte stability, low cytotoxicity and low hERG channel inhibition. DprE1-IN-1 displays potent activity against both agent-susceptible and clinically isolated drug-resistant Tuberculosis strains with MICs10 CFU reduction in macrophages.
• Target Antigen: Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/dpre1-in-1-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(OCC)NC(C1=C(NC(C2=CC=C(S(=O)(N3CCCC3)=O)C=C2)=O)SC=C1)=O
• Molecular Weight: 451.52
• References & Citations: [1]Qin R, et al. Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant tuberculosis. Eur J Med Chem. 2022;231:114145.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported