DprE1-IN-14

• Description:

  DprE1-IN-14 (Compound 77) is a DprE1 inhibitor, with an IC50 value of 2.5 nM for M. tuberculosis. DprE1-IN-14 exhibits anti-tuberculosis activity, with an MIC₉₀ of 0.3 μM for the M. tuberculosis mc26230 strain. DprE1-IN-14 mainly shows bacteriostatic activity, demonstrating a time-dependent bactericidal effect at 10-fold MIC concentrations. DprE1-IN-14 can be used in anti-tuberculosis research[1].

• UNSPSC:

  12352005

• Target:

  Bacterial

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Smiles:

  O=C(NCC1=CC=C(C2=CC=C(F)C=C2)N=C1)C3=NC([N+]([O-])=O)=CC=C3

• Molecular Formula:

  C18H13FN4O3

• Molecular Weight:

  352.32

• References & Citations:

  [1]Thompson AM, et al. Advancing the antituberculosis activity of nitropicolinic acids and amides. Eur J Med Chem. 2026 Jan 15;302 (Pt 2) :118324.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported