DprE1-IN-5

• UNSPSC Description:

  DprE1-IN-5 (Compound 10) is a DprE1 inhibitor. DprE1-IN-5 has anti-TB activity against Mtb H37Rv strain (MIC: 4 μM). DprE1-IN-5 also has antimycobacterial activity against drug-resistant strains. DprE1-IN-5 has high microsomal stability[1].

• Target Antigen:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/dpre1-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1NC(N2CCOCC2)=NC3=C1N(CC4=CC=C5C=CC=CC5=C4)C=N3

• Molecular Weight:

  361.40

• References & Citations:

  [1]Finger V, et al. 2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1. Eur J Med Chem. 2023 Oct 5;258:115611.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported