Tubulin polymerization-IN-57

Tubulin polymerization-IN-57

• CAS Number: 95385-38-9
• UNSPSC Description: Tubulin polymerization-IN-57 (compound 5a) is a tubulin inhibitor and is an α-naphthoxy-substituted carbendazim (HY-13582) derivative. Tubulin polymerization-IN-57 induces mitotic arrest and inhibits cancer cell proliferation[1].
• Target Antigen: Microtubule/Tubulin
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/tubulin-polymerization-in-57.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(OC)NC1=NC2=CC(OC3=C4C=CC=CC4=CC=C3)=CC=C2N1
• Molecular Weight: 333.34
• References & Citations: [1]Cano-González L et al. Structure-Based Optimization of Carbendazim-Derived Tubulin Polymerization Inhibitors through Alchemical Free Energy Calculations. J Chem Inf Model. 2023 Nov 27;63(22):7228-7238.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported