Tubulin polymerization-IN-39
CAT:
804-HY-151982
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Tubulin polymerization-IN-39
- UNSPSC Description: Tubulin polymerization-IN-39 is a tubulin polymerization inhibitor (IC50: 4.9 μM). Tubulin polymerization-IN-39 occupies the colchicine-binding site. Tubulin polymerization-IN-39 inhibits cancer cell proliferation[1].
- Target Antigen: Microtubule/Tubulin
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton
- Applications: Cancer-programmed cell death
- Field of Research: Cancer; Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/tubulin-polymerization-in-39.html
- Solubility: 10 mM in DMSO
- Smiles: COC1=CC=C(C=C1O)C2=CC=NC3=NC(NC4=CC(OC)=C(C(OC)=C4)OC)=NN23
- Molecular Weight: 423.42
- References & Citations: [1]Chen L, et al. Rational design, synthesis and biological evaluation of novel 2-(substituted amino)-[1,2,4]triazolo[1,5-a]pyrimidines as novel tubulin polymerization inhibitors. Eur J Med Chem. 2022 Dec 15;244:114864.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported