CCR1 antagonist 10

• UNSPSC Description:

  CCR1 antagonist 10 (example 1) is a potent and orally active CCR1 antagonist. CCR1 antagonist 10 inhibits 125I-MIP-1α binding to THP-1 cell membranes with an Ki value of 2.3 nM[1].

• Target Antigen:

  CCR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/mln-3897.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC=C(OCC2=NC=CC=C2/C3=C\CCN4CC(C)(C)[C@@](O)(C5=CC=C(Cl)C=C5)CC4)C3=C1)O

• Molecular Weight:

  519.03

• References & Citations:

  [1]Kenneth G. Carson, et al. Ccr1 antagonists for the treatment of i.a. demyelinating inflammatory disease. WO2004043965A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1010731-97-1