SB 268262

• Description :

  CGRP antagonist 4 is an antagonist of calcitonin gene-related peptide (CGRP) receptor. CGRP antagonist 4 shows the highest affinity for CGRP receptors in the human brain. CGRP antagonist 4 can be used to study the binding properties of non-peptide calcitonin gene-related peptide (CGRP) receptor antagonist (gepants) in rat, pig and human menes [1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H319

• Target :

  Others

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cgrp-antagonist-4.html

• Purity :

  99.9

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N(C)C1=CC=CC=C1C)C2=CC=C(S(C3=NC=CS3)=O)C([N+]([O-])=O)=C2

• Molecular Formula :

  C18H15N3O4S2

• Molecular Weight :

  401.46

• Precautions :

  H302, H319

• References & Citations :

  [1]Warfvinge K, et al. The Presence of Calcitonin Gene-Related Peptide and Its Receptors in Rat, Pig and Human Brain: Species Differences in Calcitonin Gene-Related Peptide Pharmacology. Pharmacology. 2019;104 (5-6) :332-341.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [217438-17-0]