CCR1 antagonist 11 (hydrochloride)

CCR1 antagonist 11 (hydrochloride)

• UNSPSC Description: CCR1 antagonist 11 hydrochloride (A1B1) is an orally active CCR1 antagonist with the IC50 values of 0.03 μM, 0.58 μM and 0.32 μM for hCCR1, mCCR1 and rCCR1, respectively. CCR1 antagonist 11 hydrochloride can be used in the study of rheumatoid arthritis and other related inflammatory diseases[1].
• Target Antigen: CCR
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/ccr1-antagonist-11-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: C[C@@H]1CN(CCN1C(/C=C/C2=C(NC(C)=O)C=C(Cl)C=C2)=O)CC3=CC=C(F)C=C3.Cl
• Molecular Weight: 466.38
• References & Citations: [1]Laszlo Revesz, et al. Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5160-4.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported