ZMF-23

• Description:

  ZMF-23 is a PAK1/HDAC6 dual inhibitor. ZMF-23 inhibits PAK1 and HDAC6 regulated aerobic glycolysis and migration. ZMF-23 induces TNF-α-regulated necroptosis, and further enhances apoptosis. ZMF-23 inhibits the Warburg effect and cell migration. ZMF-23 can be used for research of triple-negative breast cancer (TNBC) [1].

• UNSPSC:

  12352005

• Target:

  HDAC; PAK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/zmf-23.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=CC(Cl)=CC=C1C2=CC3=CN=C(NC4CC4)N=C3N(CCCCCC(NO)=O)C2=O

• Molecular Formula:

  C22H23Cl2N5O3

• Molecular Weight:

  476.36

• References & Citations:

  [1]Zhang J, et al. ZMF-23 that triggers tubulin-stathmin regulated cell death in triple negative breast cancer. Int J Biol Macromol. 2023 Aug 14;251:126348.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported