ZMF-10

• Description:

  ZMF-10 is a highly potent PAK1 inhibitor, with IC50s of 174 nM, 1.038 μM and 1.372 μM for PAK1, PAK2 and PAK3, respectively. ZMF-10 can inhibit PAK1 activity to affect PAK1-regulated apoptosis, ER-Stress and migration in MDA-MB-231 cells. ZMF-10 can be used for researching anticancer[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; PAK

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/zmf-10.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1CCN(CC1)C2=C3C=NNC3=NC=N2)NC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4

• Molecular Formula:

  C19H17F6N7O

• Molecular Weight:

  473.37

• References & Citations:

  [1]Zhang J, et al. Design, synthesis and biological evaluation of 1H-pyrazolo [3,4-d]pyrimidine derivatives as PAK1 inhibitors that trigger apoptosis, ER stress and anti-migration effect in MDA-MB-231 cells. Eur J Med Chem. 2020;194:112220.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PAK1; PAK2; PAK3

• CAS Number:

  [2415295-37-1]