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ZMF-10

CAT: 0804-HY-146786Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146786Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZMF-10 is a highly potent PAK1 inhibitor, with IC50s of 174 nM, 1.038 μM and 1.372 μM for PAK1, PAK2 and PAK3, respectively. ZMF-10 can inhibit PAK1 activity to affect PAK1-regulated apoptosis, ER-Stress and migration in MDA-MB-231 cells. ZMF-10 can be used for researching anticancer[1].
CAS Number
2415295-37-1
UNSPSC
12352005
Target
Apoptosis; PAK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zmf-10.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1CCN(CC1)C2=C3C=NNC3=NC=N2)NC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
Molecular Formula
C19H17F6N7O
Molecular Weight
473.37
References & Citations
[1]Zhang J, et al. Design, synthesis and biological evaluation of 1H-pyrazolo [3,4-d]pyrimidine derivatives as PAK1 inhibitors that trigger apoptosis, ER stress and anti-migration effect in MDA-MB-231 cells. Eur J Med Chem. 2020;194:112220.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAK1; PAK2; PAK3

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