Antiproliferative agent-34

Antiproliferative agent-34

• CAS Number: 9007-83-4
• UNSPSC Description: Antiproliferative agent-34 (Compound A14) is a multi-target kinase inhibitor, with an IC50 of 177 nM and 1567 nM for EGFR L858R/T790M and EGFR WT. Antiproliferative agent-34 also inhibits JAK2, ROS1, FLT3, FLT4, PDGFRα with IC50 of 30.93, 106.90, 108.00, 226.60, 42.53 nM. Antiproliferative agent-34 inhibits H1975 and HCC827 cells proliferation with IC50 values below 40 nM under normoxic condition, and the anti-proliferation potency achieves 4–6-fold improvement (IC50 values [1].
• Target Antigen: EGFR
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/antiproliferative-agent-34.html
• Solubility: 10 mM in DMSO
• Smiles: CN(C1=C2C=CC=C1)C=C2C3=NC(NC4=CC(OCCOCCN5C=CN=C5[N+]([O-])=O)=C(OC)C=C4)=NC=C3
• Molecular Weight: 529.55
• References & Citations: [1]Jia T, et al. Discovery of novel hypoxia-activated, nitroimidazole constructed multi-target kinase inhibitors on the basis of AZD9291 for the treatment of human lung cancer. Bioorg Med Chem. 2023 Aug 15;91:117384.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported