Antiproliferative agent-4

Antiproliferative agent-4

• CAS Number: 9007-83-4
• UNSPSC Description: Antiproliferative agent-4 (compound 2y) has excellent anti-proliferative activity against certain cancer cell lines. Antiproliferative agent-4 reduces the mitochondrial membrane potential, and increases the apoptosis rate and the level of ROS on EC109. Antiproliferative agent-4 inhibits tumour growth in nude mice, with low toxicity[1].
• Target Antigen: Apoptosis; Reactive Oxygen Species
• Type: Reference compound
• Related Pathways: Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/antiproliferative-agent-4.html
• Solubility: 10 mM in DMSO
• Smiles: CC1(C)CCC[C@]2(COC(O)=O)C1C[C@@H](O)[C@]3(C4=O)C2[C@@H](O)C[C@@H](C4=C)[C@H]3OC(C5=CC=C(CCl)C=C5)=O
• Molecular Weight: 547.04
• References & Citations: [1]Huo JF, et al. Synthesis and in vitro and in vivo biological evaluation of novel derivatives of flexicaulin A as antiproliferative agents. Eur J Med Chem. 2020;208:112789.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported