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Antiproliferative agent-34

CAT: 0013-GTR19218703-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19218703-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antiproliferative Agent-34 (Compound A14) is a multitarget kinase inhibitor with potent activity against mutant EGFR (L858R/T790M, IC50 177 nM) and several other kinases including JAK2 and FLT3. It demonstrates strong antiproliferative effects in NSCLC cell lines like H1975, with potency significantly enhanced under hypoxic conditions. This profile supports its research application in studying oncogenic signaling and hypoxia-driven resistance in cancer models.
CAS Number
2910858-34-1
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
O=[N+] (C1=NC=CN1CCOCCOC (C=C2NC3=NC=CC (C (C4=CC=CC=C45) =CN5C) =N3) =C (C=C2) OC) [O-]
Molecular Formula
C27H27N7O5
Molecular Weight
529.55
Storage Conditions
-20°C
Notes
For research use only.

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