Antiproliferative agent-71

CAT: 0804-HY-176521-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-176521-01Size:1 mg
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Description
Antiproliferative agent-71 (Compound II-5) is an orally active dual inhibitor against the androgen receptor (AR) and bromodomain-containing protein 4 (BRD4) . Antiproliferative agent-71 effectively inhibits tumor cell growth and proliferation by simultaneously blocking the functions of AR and BRD4. Antiproliferative agent-71 is promising for research of prostate cancer[1].
CAS Number
[3083307-42-7]
UNSPSC
12352005
Target
Androgen Receptor; Epigenetic Reader Domain
Related Pathways
Epigenetics; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
N#CC1=C(OC)C=C(O[C@@H]2C(C)(C)[C@@H](NC(C3=CN=C(N4CCC5(CC(OC6=CC=C(C7=N[C@@H](CC8=NC=CO8)C9=NN=C(C)N9C%10=C7C(C)=C(C)S%10)C=C6)C5)CC4)N=C3)=O)C2(C)C)C=C1
Molecular Formula
C50H54N10O5S
Molecular Weight
907.09
References & Citations
[1]Kyle J. Eastman, et al. Heterobifunctional compounds and methods of treating disease. WO2025085738A1. 2025-04-24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4

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