PRMT4-IN-2

• Description:

  PRMT4-IN-2 (compound 55) is a pan-inhibitor of protein arginine methyltransferase (PRMT) with IC50s of 92 nM (PRMT4), 436 nM (PRMT6), 460 nM (PRMT1), 823 nM (PRMT8), 1.386 μM (PRMT3) [1].

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/prmt4-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@@H]1CN(CCNC)CC1)C2=CC3=NC=NC(NC4=CC=C(CN)C=C4)=C3C=C2

• Molecular Formula:

  C23H29N7O

• Molecular Weight:

  419.52

• References & Citations:

  [1]Bhattacharya D, et al. Development of selective class I protein arginine methyltransferase inhibitors through fragment-based drug design approach. Eur J Med Chem. 2023 Nov 15;260:115713..

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported