PRMT4-IN-1

• Description:

  PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC50=3.2 nM) . PRMT4-IN-1 inhibits MCF7 relative viability[1].

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/prmt4-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (OC) C1=CC (O) =C2C=C (NC (NCCCCNC (NC/C=C/[C@H]3O[C@@H] (N4C=NC5=C (N) N=CN=C45) [C@H] (O) [C@@H]3O) =N) =O) C=CC2=C1

• Molecular Formula:

  C30H36N10O7

• Molecular Weight:

  648.67

• References & Citations:

  [1]Iannelli G, et al. Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J Med Chem. 2022 Sep 8;65 (17) :11574-11606.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PRMT1; PRMT3; PRMT4; PRMT5; PRMT6; PRMT7; PRMT8