PRMT4-IN-3

• Description:

  PRMT4-IN-3 (compound 56) is a potent inhibitor of class I protein arginine methyltransferase (PRMT), targeting PRMT4 (IC50: 37 nM) and PRMT4 (IC50: 253 nM) [1].

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/prmt4-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (N[C@H]1CN (CCNC) CC1) C2=CC3=NC=NC (NC4=CC=C (CN) C=C4) =C3C=C2

• Molecular Formula:

  C23H29N7O

• Molecular Weight:

  419.52

• References & Citations:

  [1]Bhattacharya D, et al. Development of selective class I protein arginine methyltransferase inhibitors through fragment-based drug design approach. Eur J Med Chem. 2023 Nov 15;260:115713..

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported