BI 7446

• UNSPSC Description:

  BI 7446 is a cyclic dinucleotide (CDN)-based potent and selective stimulator of interferon genes (STING) agonist. BI 7446 can activate all five STING variants in cells and induce tumor-specific immune-mediated tumor rejection. BI 7446 can be used for immuno-oncology research[1].

• Target Antigen:

  STING

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/bi-7446.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H]1[C@@H](O2)[C@H](N3C(C=NNC4=O)=C4N=C3)O[C@@H]1CO[P@](O[C@H]5[C@@H](F)[C@H](N6C(N=CN=C7N)=C7N=C6)O[C@@H]5CO[P@]2(S)=O)(S)=O

• Molecular Weight:

  693.52

• References & Citations:

  [1]Kuttruff CA, et al. Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer. J Med Chem. 2023 Jul 27;66(14):9376-9400.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2767011-00-5