BI-1408

• Description:

  BI-1408 is a potent γ secretase modulator with an IC50 of 0.04 μM for Aβ42[1].

• UNSPSC:

  12352005

• Target:

  Amyloid-β; γ-secretase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling; Stem Cell/Wnt

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/BI-1408.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC(F)=CC=C1C2=CC=CN3C2=NC(N[C@@H]4CCC(N(CC)N=C5)=C5C4)=N3

• Molecular Formula:

  C22H23FN6

• Molecular Weight:

  390.46

• References & Citations:

  [1]Gerlach K, et al. Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators. Bioorg Med Chem. 2018 Jul 23;26 (12) :3227-3241.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2231075-94-6]