BI-1408

• Description :

  BI-1408 is a potent γ secretase modulator with an IC50 of 0.04 μM for Aβ42[1].

• UNSPSC :

  12352005

• Target :

  Amyloid-β; γ-secretase

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling; Stem Cell/Wnt

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/BI-1408.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=CC(F)=CC=C1C2=CC=CN3C2=NC(N[C@@H]4CCC(N(CC)N=C5)=C5C4)=N3

• Molecular Formula :

  C22H23FN6

• Molecular Weight :

  390.46

• References & Citations :

  [1]Gerlach K, et al. Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators. Bioorg Med Chem. 2018 Jul 23;26 (12) :3227-3241.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2231075-94-6]