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BI-1408

CAT: 0804-HY-112282Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112282Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BI-1408 is a potent γ secretase modulator with an IC50 of 0.04 μM for Aβ42[1].
CAS Number
[2231075-94-6]
UNSPSC
12352005
Target
Amyloid-β; γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BI-1408.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(F)=CC=C1C2=CC=CN3C2=NC(N[C@@H]4CCC(N(CC)N=C5)=C5C4)=N3
Molecular Formula
C22H23FN6
Molecular Weight
390.46
References & Citations
[1]Gerlach K, et al. Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators. Bioorg Med Chem. 2018 Jul 23;26 (12) :3227-3241.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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