RegisterLogin

BI-2852

CAT: 0804-HY-126247-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-126247-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM) . BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
CAS Number
[2375482-51-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bi-2852.html
Purity
99.46
Solubility
DMSO : 55 mg/mL (ultrasonic)
Smiles
OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62)N7)=C1C7=O
Molecular Formula
C31H28N6O2
Molecular Weight
516.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Kessler D, et al. Drugging an undruggable pocket on KRAS. Proc Natl Acad Sci U S A. 2019 Aug 6; 116 (32) :15823-15829.|[2]Dirk Kessler, et al. Drugging all RAS isoforms with one pocket. FUTURE MEDICINAL CHEMISTRY
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras

Related Products

CatalogName
HY-12995BI 665915
HY-162660BI-9508
HY-P991192-01BI-1808
HY-P991488-01BI-765423
HY-112282BI-1408
HY-129550-01BI-4020
HY-161275-01BI-4732
HY-18595-01BI 224436
HY-18071-01BI-9627
HY-18955-01BI-847325

Alternative Products

CatalogName
BA5763-5BI-2852
A24527-5BI-2852 5mg
M36442-01(R) -BI-2852
A24527-50BI-2852 50mg
T207778-01BI 2852 FL
MBS5814586(R)-BI-2852
A24527-10BI-2852 10mg
A24527-100BI-2852 100mg
M11401-01SKI-2852
NBP2-46633Mouse Monoclonal MOG Antibody (2852)

Popular Products