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BI-4464

CAT: 0804-HY-124625-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124625-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BI-4464 is a highly selective, ATP competitive PTK2/FAK protein kinase inhibitor with an IC50 value of 17 nM. BI-4464 is a FAK ligand and linker conjugate. BI-4464 can be used to construct proteolysis targeting chimeras (PROTACs), such as PROTAC FAK degrader 4 (HY-178467). PROTAC FAK degrader 4 is a highly potent and selective FAK PROTAC degrader[1][2][3].
CAS Number
1227948-02-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
FAK; Target Protein Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/bi-4464.html
Purity
98.64
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=C(NC1CCN(C)CC1)C2=CC=C(NC3=NC=C(C(F)(F)F)C(OC4=CC=CC(CC5)=C4C5=O)=N3)C(OC)=C2
Molecular Formula
C28H28F3N5O4
Molecular Weight
555.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62 (5) :2508-2520.|[2]Moni BM, et al. Ebola Virus GP Activates Endothelial Cells via Host Cytoskeletal Signaling Factors. Viruses. 2022 Jan 13;14 (1) :142. |[3]Liu C, et al. Structure-guided design of a potent focal adhesion kinase (FAK) degrader via ternary complex modeling and molecular dynamics simulation. Bioorg Chem. 2025 Oct;165:109017.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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