BI-4394

• Description :

  BI-4394 (MMP13-IN-3), a chemical probe, is a potent, selective, and orally active MMP-13 inhibitor (IC50=1 nM[1]) for the potential treatment of osteoarthritis[2]. BI-4394 is >1000 selective over other MMPs[1].

• Product Name Alternative :

  MMP13-IN-3

• UNSPSC :

  12352005

• Target :

  MMP

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/bi-4394.html

• Purity :

  99.09

• Solubility :

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(C(N1)=CC2=C1C=CC(C3=CC(C(NCC4=CC=C(C(O)=O)C=C4)=O)=NN3C)=C2)OCC

• Molecular Formula :

  C24H22N4O5

• Molecular Weight :

  446.46

• References & Citations :

  [1]Taylor SJ, et al. Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J Med Chem. 2011 Dec 8;54 (23) :8174-87.|[2]Ruminski PG, et al. Discovery of N- (4-Fluoro-3-methoxybenzyl) -6- (2- (((2S,5R) -5- (hydroxymethyl) -1,4-dioxan-2-yl) methyl) -2H-tetrazol-5-yl) -2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis. J Med Chem. 2016 Jan 14;59 (1) :313-27.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MMP-10; MMP-13; MMP-14; MMP-2; MMP-9

• CAS Number :

  [1222173-37-6]