BI-4394

CAT: 0804-HY-124029-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-124029-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
BI-4394 (MMP13-IN-3), a chemical probe, is a potent, selective, and orally active MMP-13 inhibitor (IC50=1 nM[1]) for the potential treatment of osteoarthritis[2]. BI-4394 is >1000 selective over other MMPs[1].
CAS Number
[1222173-37-6]
Product Name Alternative
MMP13-IN-3
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bi-4394.html
Purity
99.09
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C(N1)=CC2=C1C=CC(C3=CC(C(NCC4=CC=C(C(O)=O)C=C4)=O)=NN3C)=C2)OCC
Molecular Formula
C24H22N4O5
Molecular Weight
446.46
References & Citations
[1]Taylor SJ, et al. Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J Med Chem. 2011 Dec 8;54 (23) :8174-87.|[2]Ruminski PG, et al. Discovery of N- (4-Fluoro-3-methoxybenzyl) -6- (2- (((2S,5R) -5- (hydroxymethyl) -1,4-dioxan-2-yl) methyl) -2H-tetrazol-5-yl) -2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis. J Med Chem. 2016 Jan 14;59 (1) :313-27.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-10; MMP-13; MMP-14; MMP-2; MMP-9

Related Products

CatalogName
HY-112282BI-1408
HY-P991488-01BI-765423
HY-P991192-01BI-1808
HY-150023-01BI-1622
HY-123800-01BI 187004
HY-111925-01BI-749327
HY-124772-01BI-2545
HY-126253-01BI-4916
HY-124063-01BI-1935
HY-108705-01BI-3802

Alternative Products

CatalogName
564102BI-4394
B2798-500BI
S0099Scavenger Receptor BI (SR-BI)
MBS131573BI-9564 (BI 9564; BI9564)
MBS616702-01Natriuretic Peptide Receptor Bi (NPR-Bi)
GWB-4A76FASCAVENGER RECEPTOR BI (SR-BI), Antibody
MBS3612981-01BI-671800
MBS3610476-01BI-6C9
MBS3604685-01BI-D1870
MBS3614593-01BI-1935

Popular Products