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CSF1R-IN-15

CAT: 0804-HY-155001Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155001Size:1 Each
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Description
CSF1R-IN-15 (compound 23) is an inhibitor targeting CSF1R. The colony-stimulating factor-1 receptor (CSF1R) is a tyrosine kinase embedded in the cell membrane of macrophages. The receptor is activated by colony-stimulating factor-1 (CSF-1) and interleukin-34, and signaling via CSF1R is crucial for the differentiation, proliferation, and survival of macrophages[1].
CAS Number
2925744-43-8
UNSPSC
12352005
Target
C-Fms
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/csf1r-in-15.html
Solubility
10 mM in DMSO
Smiles
CN(C1=NC=NC2=C1C=C(N2)C3=CC=C(C=C3)CO)CC4=CC=CC(C)=C4
Molecular Formula
C22H22N4O
Molecular Weight
358.44
References & Citations
[1]Aarhus TI, et al. Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form. J Med Chem. 2023 May 25;66 (10) :6959-6980.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Csf1R-IN-15
CAS Number2925744-43-8
PubChem CID168069186
IUPAC Name[4-[4-[methyl-[(3-methylphenyl)methyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]methanol
Molecular FormulaC22H22N4O
Molecular Weight358.4
XLogP3.8
Topological Polar Surface Area65
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity467
SMILES
CC1=CC(=CC=C1)CN(C)C2=NC=NC3=C2C=C(N3)C4=CC=C(C=C4)CO
InChI
InChI=1S/C22H22N4O/c1-15-4-3-5-17(10-15)12-26(2)22-19-11-20(25-21(19)23-14-24-22)18-8-6-16(13-27)7-9-18/h3-11,14,27H,12-13H2,1-2H3,(H,23,24,25)
InChIKey
KXUSCHVJJBSONI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Csf1R-IN-15
CAS: 2925744-43-8
CID: 168069186
Formula: C22H22N4O
MW: 358.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight358.4
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass358.17936134
Monoisotopic Mass358.17936134
Topological Polar Surface Area65 Ų
Heavy Atom Count27
Formal Charge0
Complexity467
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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