Ara-SH

• Description :

  Ara-SH is a Cytarabine mercaptopropionic acid-substituted derivative. Ara-SH is used as the trigger to fabricate a smart Cytarabine and Venetoclax-coloaded nanoparticle (AV-NP) through self-assembly. Ara-SH exhibits remarkable synergistic antileukemia effects in vitro and in vivo[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ara-sh.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=NC(N([C@@H]2O[C@@H]([C@H]([C@@H]2O)O)CO)C=C1)=O)CCS

• Molecular Formula :

  C12H17N3O6S

• Molecular Weight :

  331.34

• References & Citations :

  [1]Lejiao Jia, et al. Smart and Generalizable Cytarabine Derivative-Triggered Nanoparticles for Synergistic Therapy of Relapsed/Refractory Acute Myeloid Leukemia. ACS Appl Mater Interfaces. 2023 Jun 14;15 (23) :27624-27637.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported