SH-5

• Description :

  SH-5 is a potent AKT inhibitor. SH-5 potentiates the apoptosis induced by tumor necrosis factor. SH-5 blocks NF-kB activation induced by TNF-a, lipopolysaccharide (HY-D1056), phorbol ester (HY-18739), and cigarette smoke[1].

• UNSPSC :

  12352211

• Target :

  Akt; Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; PI3K/Akt/mTOR

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sh-5.html

• Smiles :

  CCCCCCCCCCCCCCCCCCOC[C@@H](OC)COP(O[C@@H]1[C@@H](C[C@H]([C@@H]([C@H]1O)O)O)OC)(O)=O

• Molecular Formula :

  C29H59O10P

• Molecular Weight :

  598.75

• References & Citations :

  [1]Sethi G, et al. SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. Biochem Pharmacol. 2008 Dec 1;76 (11) :1404-16.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [701976-54-7]