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SH-5

CAT: 0804-HY-100702Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-100702Size:1 Each
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Description
SH-5 is a potent AKT inhibitor. SH-5 potentiates the apoptosis induced by tumor necrosis factor. SH-5 blocks NF-kB activation induced by TNF-a, lipopolysaccharide (HY-D1056), phorbol ester (HY-18739), and cigarette smoke[1].
CAS Number
[701976-54-7]
UNSPSC
12352211
Target
Akt; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sh-5.html
Smiles
CCCCCCCCCCCCCCCCCCOC[C@@H](OC)COP(O[C@@H]1[C@@H](C[C@H]([C@@H]([C@H]1O)O)O)OC)(O)=O
Molecular Formula
C29H59O10P
Molecular Weight
598.75
References & Citations
[1]Sethi G, et al. SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. Biochem Pharmacol. 2008 Dec 1;76 (11) :1404-16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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