SH-5

• UNSPSC Description:

  SH-5 is a potent AKT inhibitor. SH-5 potentiates the apoptosis induced by tumor necrosis factor. SH-5 blocks NF-kB activation induced by TNF-a, lipopolysaccharide (HY-D1056), phorbol ester (HY-18739), and cigarette smoke[1].

• Target Antigen:

  Akt; Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;PI3K/Akt/mTOR

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sh-5.html

• Smiles:

  CCCCCCCCCCCCCCCCCCOC[C@@H](OC)COP(O[C@@H]1[C@@H](C[C@H]([C@@H]([C@H]1O)O)O)OC)(O)=O

• Molecular Weight:

  598.75

• References & Citations:

  [1]Sethi G, et al. SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. Biochem Pharmacol. 2008 Dec 1;76(11):1404-16.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  701976-54-7