SH-273

• Description :

  SH-273 is a dual targeting compound. SH-273 has dual function to stimulate STING function (EC50: 100 nM) and inhibits PI3Kγ (IC50: 7 nM) . SH-273 can be used in the research of pancreatic cancer[1].

• UNSPSC :

  12352005

• Target :

  PI3K; STING

• Related Pathways :

  Immunology/Inflammation; PI3K/Akt/mTOR

• Field of Research :

  Cancer

• Smiles :

  O=C1C(C2=C3)=C(C(N1CCC(OCCN4C=C(C5=C6C(C=C(N(C7=CC=CC=C7)C6=O)[C@H](C)NC(C8=C9N(C=CC=N9)N=C8N)=O)=CC=C5)N=N4)=O)=O)SC2=CC(OC)=C3OC

• Molecular Formula :

  C43H36N10O8S

• Molecular Weight :

  852.87

• References & Citations :

  [1]Li C, et al. Overcoming B regulatory cell induced STING resistance by dual functional albumin nanomedicine to prolong survival of pancreatic cancer. Cancer Research, 2024, 84 (6_Supplement) : 6534-6534.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3084159-97-4]